● Now Accepting New Practitioners

The drug-free discomfort solution your patients will thank you for.

Free wholesale access for licensed practitioners — unlock wholesale pricing, a branded marketing library, and a clinically-backed product patients actually re-order.

Free to join    No order minimums    Approved in 1–2 days

Dr. Beth DuPree applying a Signal Relief patch

98%

of active-patch participants experienced pain reduction at some point within 72 hours.*

~46%

wholesale margin vs. retail MSRP

1,000s

of 5★ reviews from real patients

*Based on a 2025 placebo-controlled study of 91 active-patch users with chronic back or knee pain. Individual results may vary.

Everything you need to add Signal Relief to your practice — day one.

Free access for approved practitioners. The product, the pricing, the marketing — handled.

Wholesale pricing on the full catalog

Up to ~46% off MSRP on the full Signal Relief catalog. No minimums, no contracts, no subscription fees.

Done-for-you marketing library

Patient testimonial videos, in-office posters, social graphics, and education sheets — all branded and ready to use.

A clinically-backed product

98% of active-patch participants experienced pain reduction at some point within the 72-hour treatment window.* Drug-free, non-invasive.

Doctor-vetted, patient-loved

Trusted by MDs, DOs, DCs, PTs, and OTs across the country. The kind of product patients actually call back about.

A real new revenue line

No insurance billing. No claim denials. Cash margin from day one — restocked as patients re-order.

Risk-free for you and your patients

1-year warranty + feel-better-or-money-back guarantee on every unit. Patients say yes more easily.

*Based on a 2025 placebo-controlled study of 91 active-patch users with chronic back or knee pain. Individual results may vary.

The Margin Math

Real wholesale and MSRP pricing on the catalog you'll have access to.

Signal Relief Step (3 Pack)

wholesale  ·  Retails for $447


Cash Margin

+$177

40% per unit

★ Best Seller

Signal Relief Step (5 Pack)

wholesale  ·  Retails for $745


Cash Margin

+$320

43% per unit

Signal Relief Step (10 Pack)

wholesale  ·  Retails for $1,490


Cash Margin

+$690

46% per unit

No insurance billing. No prior auth. No claim denials. Cash margin recognized on order.

"It's a game changer."

Hear from the doctors already prescribing Signal Relief in their practices.

Dr. Avery Jackson
"I've seen this patch work in my life and others"
Dr. Beth DuPree
"You have nothing to lose but the discomfort that is holding you back"
Dr. John E. Storheim
"I believe it will be a great non-invasive way to treat the daily aches and pains"
Jeremy Jackson
"It's a game changer"
Patient using Signal Relief patch

Clinically Backed

Drug-free relief, evaluated in a double-blind, placebo-controlled study.

In a 2025 double-blind, placebo-controlled study, 91 participants received active Signal Relief Patches and 21 received placebo patches. Among the active-patch group, 71% (65/91) experienced pain reduction within 15 minutes, and 98% (89/91) experienced pain reduction at some point within the 72-hour treatment window.*

71%

Experienced pain reduction within 15 minutes*

98%

Experienced pain reduction at some point within 72 hours*

*Based on a 2025 placebo-controlled study of 91 active-patch users with chronic back or knee pain. Individual results may vary.

Why your practice will benefit

  • Improved Patient Outcomes
  • Market Differentiation
  • Additional Revenue Stream
  • Enhanced Patient Loyalty

Read the full white paper →

The Technology

Inside the Signal Relief Patch, patented technology is designed to work alongside the body's natural electrical system to pick up messages of discomfort. Microscopic particles between the layers of the patch act as an antenna, helping to quiet the noise and reduce the impact of discomfort.

  • Reduces discomfort in as little as seconds
  • Works on musculoskeletal discomfort
  • Easy to apply anywhere on the body
  • 1-Year product warranty
  • Feel better or your money back guarantee

Learn How It Works →

Signal Relief patch technology layers

How It Works

Free access. Three simple steps.

No subscription, no contracts. Apply, get verified, start ordering at wholesale.

Step 01

Apply

Submit your license details in under 2 minutes. We verify every applicant.

Step 02

Get Approved

Most applications are reviewed within 1–2 business days. You'll get an invite link by email.

Step 03

Order at Wholesale

Set your password, log in, and unlock the full catalog plus the marketing library.

FAQ

Common questions

Who qualifies for the wholesale program?

Licensed medical practitioners — MDs, DOs, DCs, NPs, PAs, PTs, OTs, and similar credentialed professionals practicing in the United States. We verify license details during application review.


How much does access cost?

Nothing. Wholesale access is free for approved practitioners. You only pay for the product you order — at wholesale pricing.


How much can I actually make per unit?

It depends on the SKU. As an example, the Signal Relief Step 5-Pack is $425 wholesale and retails for $745 — that's $320 of cash margin per pack, with no insurance friction. Most practitioners price at MSRP and resell within days, not months.


Is there a contract or minimum order?

No contracts and no order minimums. Order what you need, when you need it.


What does the marketing library include?

Patient testimonial videos you can play in your waiting room, branded one-pagers, social-ready graphics, and clinical education materials. New assets are added regularly.


How long does approval take?

Most applications are reviewed within 1–2 business days. Once approved, you'll get an invite link to set your password and start ordering immediately.

Join the medical practitioners offering Signal Relief — and start changing the way your patients deal with discomfort.

Free for licensed practitioners · No contracts · Approved in 1–2 business days

Discover how Signal Relief's clinically-backed pain relief technology can seamlessly integrate into your practice, providing your patients with effective, non-invasive solutions.
Signal Relief is a CaliberMed company - Signal Relief and JOVI are general wellness products intended to help promote physical activity and a healthy lifestyle. Signal does not claim to treat, cure or diagnose disease. If you have concerns about your personal health conditions, please consult your physician. Do not use the Signal Relief patch if you have a pacemaker, implantable pain management device, defibrillator, or other neuromodulation implantable device. Do not use if you are pregnant. The Signal Relief patch is not intended to be cut or altered in any way and is not intended for internal use.
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